##FastQC	0.11.9
>>Basic Statistics	pass
#Measure	Value
Filename	SRR12391891_2.fastq.gz
File type	Conventional base calls
Encoding	Sanger / Illumina 1.9
Total Sequences	29952310
Sequences flagged as poor quality	0
Sequence length	35-151
%GC	51
>>END_MODULE
>>Per base sequence quality	pass
#Base	Mean	Median	Lower Quartile	Upper Quartile	10th Percentile	90th Percentile
1	30.7917803000837	32.0	32.0	32.0	32.0	32.0
2	30.526284483567377	32.0	32.0	32.0	32.0	32.0
3	30.692622104939485	32.0	32.0	32.0	32.0	32.0
4	30.715862916749995	32.0	32.0	32.0	32.0	32.0
5	30.725462443464295	32.0	32.0	32.0	32.0	32.0
6	34.07586857240727	36.0	36.0	36.0	32.0	36.0
7	34.16269820257603	36.0	36.0	36.0	32.0	36.0
8	34.1194928538066	36.0	36.0	36.0	32.0	36.0
9	34.100116819036664	36.0	36.0	36.0	32.0	36.0
10-14	34.059616002905955	36.0	36.0	36.0	32.0	36.0
15-19	34.02002224202407	36.0	36.0	36.0	32.0	36.0
20-24	33.95124167718617	36.0	36.0	36.0	32.0	36.0
25-29	33.84104849342171	36.0	36.0	36.0	32.0	36.0
30-34	33.72529233304543	36.0	36.0	36.0	31.0	36.0
35-39	33.60115637301551	36.0	36.0	36.0	27.0	36.0
40-44	33.507771312047694	36.0	36.0	36.0	27.0	36.0
45-49	33.35825771759319	36.0	36.0	36.0	21.0	36.0
50-54	33.24891219262501	36.0	36.0	36.0	21.0	36.0
55-59	33.07057493963332	36.0	36.0	36.0	14.0	36.0
60-64	32.904260250834206	36.0	36.0	36.0	14.0	36.0
65-69	32.73074403084002	36.0	35.2	36.0	14.0	36.0
70-74	32.50269768379785	36.0	32.0	36.0	14.0	36.0
75-79	32.274983589364155	36.0	32.0	36.0	14.0	36.0
80-84	32.025927859676514	36.0	32.0	36.0	14.0	36.0
85-89	31.858006006708784	36.0	32.0	36.0	14.0	36.0
90-94	31.67452361165802	36.0	32.0	36.0	14.0	36.0
95-99	31.5203378979357	36.0	32.0	36.0	14.0	36.0
100-104	31.315984024467554	36.0	32.0	36.0	14.0	36.0
105-109	31.139645599182916	36.0	32.0	36.0	14.0	36.0
110-114	30.943549925502936	36.0	31.0	36.0	14.0	36.0
115-119	30.77472912417459	36.0	28.0	36.0	14.0	36.0
120-124	30.481664545011473	36.0	27.0	36.0	14.0	36.0
125-129	30.231284854065052	36.0	27.0	36.0	14.0	36.0
130-134	29.999895336702753	36.0	27.0	36.0	14.0	36.0
135-139	29.65047755741036	32.8	27.0	36.0	14.0	36.0
140-144	29.34228523921079	32.0	27.0	36.0	14.0	36.0
145-149	28.93344864202884	32.0	27.0	36.0	14.0	36.0
150-151	27.002335370622077	29.5	17.5	34.0	14.0	36.0
>>END_MODULE
>>Per sequence quality scores	pass
#Quality	Count
2	19528.0
3	1631.0
4	415.0
5	87.0
6	131.0
7	179.0
8	255.0
9	356.0
10	451.0
11	579.0
12	677.0
13	724.0
14	3913.0
15	20487.0
16	47628.0
17	73005.0
18	80203.0
19	90236.0
20	119566.0
21	166332.0
22	229836.0
23	306447.0
24	405433.0
25	536736.0
26	700854.0
27	907572.0
28	1169161.0
29	1507284.0
30	1962488.0
31	2603638.0
32	3543846.0
33	4923791.0
34	6545311.0
35	3983530.0
>>END_MODULE
>>Per base sequence content	fail
#Base	G	A	T	C
1	25.05166622230508	9.681720167133413	13.342968963514906	51.92364464704659
2	22.514413481630953	15.730600407074213	31.212287746125504	30.542698365169326
3	26.698878030400202	18.482525092996408	19.61992060565247	35.19867627095091
4	30.87533996000054	24.41944392813032	16.3636229403465	28.34159317152264
5	28.66898360854215	27.341555582734912	19.797468647068552	24.191992161654387
6	24.4963964145158	30.771267722670686	21.069797923784705	23.66253793902881
7	20.76650528466046	17.25575842972533	38.65400284081152	23.32373344480269
8	23.244251430239224	18.459312008476896	28.491219311054305	29.80521725022957
9	23.892452189802313	19.37144561374293	29.9209031174118	26.815199079042955
10-14	23.83931600410891	25.90919253132162	24.247626138255935	26.00386532631354
15-19	25.08166625035192	24.539688941872715	25.28171453729331	25.09693027048206
20-24	24.986771081583004	24.862772108727153	25.31152883231909	24.83892797737075
25-29	24.844026624088077	25.71967604435368	23.82090238955594	25.6153949420023
30-34	25.03313126417671	24.160158157002048	24.454593383744918	26.352117195076318
35-39	25.305980676967433	24.978832210682896	23.276021061691374	26.439166050658297
40-44	25.71286134624024	24.57920195241366	23.91459000416769	25.79334669717841
45-49	25.341155950263104	24.66569527427294	24.33285265120595	25.660296124258004
50-54	25.520970472498277	25.412044337134095	23.811544446615862	25.255440743751763
55-59	24.94334411754163	25.190511724683283	24.491793069465317	25.374351088309773
60-64	25.571452317573584	23.545339584924076	24.80414815052648	26.079059946975864
65-69	25.47821015698945	24.26782543678754	24.08745775939781	26.166506646825194
70-74	25.53566033858789	24.460968676943462	23.868759371326785	26.13461161314186
75-79	26.217712332951887	23.677758806790884	23.369235136682995	26.735293723574234
80-84	25.517364592911395	23.894238211261655	23.40804785863357	27.180349337193388
85-89	25.748944506113858	24.244676784676784	23.372319825439405	26.634058883769953
90-94	26.35660296104103	24.67632781670714	23.400698839404164	25.566370382847666
95-99	25.182935815106443	24.856080509413818	24.643188208478346	25.317795467001385
100-104	25.276976114078543	25.176355692572983	24.232983573231948	25.31368462011653
105-109	25.496958319527813	24.379312015230383	24.61929869453999	25.50443097070182
110-114	25.263811407008614	25.410068457638108	23.58243309722483	25.74368703812845
115-119	25.74876679525659	24.281071718578755	24.33385126954024	25.636310216624413
120-124	26.010149527905114	24.145802795661133	24.15428468735774	25.68976298907601
125-129	26.137559811717903	25.45518674142413	21.96542560123089	26.441827845627074
130-134	26.067436592327937	24.30916229747434	23.851555271842397	25.77184583835533
135-139	26.528837455472875	23.96603866705347	23.432208500433262	26.072915377040395
140-144	26.814262530066085	23.740698340302526	23.156475261281926	26.288563868349467
145-149	27.133733789895274	23.846222309371615	22.673105388049038	26.346938512684066
150-151	27.397536293336604	12.255616292654045	27.157333573467767	33.189513840541586
>>END_MODULE
>>Per sequence GC content	warn
#GC Content	Count
0	21659.0
1	12155.0
2	2646.0
3	2603.5
4	2246.5
5	1659.0
6	1288.0
7	1119.0
8	1072.0
9	1074.5
10	1133.0
11	1222.5
12	1304.0
13	1518.5
14	1870.5
15	2174.5
16	2493.5
17	3013.5
18	3551.0
19	4101.5
20	4807.5
21	5780.0
22	7149.0
23	8876.5
24	10963.5
25	13538.5
26	16839.0
27	21909.5
28	28892.0
29	37175.5
30	48714.5
31	63932.0
32	82326.0
33	106250.0
34	149943.0
35	258006.0
36	399425.0
37	461178.0
38	457328.5
39	500011.0
40	481551.0
41	446396.5
42	505116.0
43	646826.5
44	905633.5
45	1010174.0
46	1002228.5
47	1260028.0
48	1532676.5
49	1512572.0
50	1487789.0
51	1393119.5
52	1341069.5
53	1339487.0
54	1136909.5
55	985265.5
56	930554.5
57	983222.0
58	1038022.5
59	988626.5
60	872173.0
61	804694.0
62	761527.5
63	638795.0
64	519263.0
65	410769.0
66	347323.0
67	304353.0
68	271407.0
69	257699.5
70	220455.5
71	167957.0
72	143306.0
73	126350.5
74	110874.5
75	84530.5
76	42488.0
77	32483.5
78	42451.5
79	60908.5
80	48376.0
81	24201.0
82	11284.5
83	2332.5
84	1364.0
85	1079.0
86	929.5
87	845.0
88	806.5
89	753.0
90	707.5
91	713.0
92	700.5
93	662.5
94	681.0
95	690.0
96	695.0
97	726.0
98	843.0
99	1034.0
100	2304.5
>>END_MODULE
>>Per base N content	pass
#Base	N-Count
1	0.07254866152226656
2	0.05259694494347848
3	0.052316499128113994
4	0.059781699641864014
5	0.06497996314808441
6	0.06921669814448368
7	0.06683290871388552
8	0.06878935214011873
9	0.07827109161196583
10-14	0.08071831521508692
15-19	0.09026015021879781
20-24	0.08496573386159531
25-29	0.08900081496218488
30-34	0.08544249174771495
35-39	0.052804519467249254
40-44	0.04315092721005863
45-49	0.04027082152536056
50-54	0.03959473190157127
55-59	0.04669407668394286
60-64	0.05060784571635032
65-69	0.04335987836445448
70-74	0.04513862988772004
75-79	0.04425092905109516
80-84	0.04448379883438382
85-89	0.04761505790345134
90-94	0.04188898784078295
95-99	0.04456380145151835
100-104	0.042158905210094515
105-109	0.04372672312987529
110-114	0.04453313376021239
115-119	0.03909910262517466
120-124	0.048228893814442265
125-129	0.03958429513565129
130-134	0.04394734631108442
135-139	0.03791923682136402
140-144	0.03320503699603011
145-149	0.02972433723510172
150-151	0.0324912189261287
>>END_MODULE
>>Sequence Length Distribution	warn
#Length	Count
35-39	18619.0
40-44	4127.0
45-49	4168.0
50-54	4292.0
55-59	4428.0
60-64	4909.0
65-69	5431.0
70-74	6359.0
75-79	7392.0
80-84	9178.0
85-89	10907.0
90-94	14224.0
95-99	17670.0
100-104	21484.0
105-109	24585.0
110-114	30793.0
115-119	34577.0
120-124	40498.0
125-129	46263.0
130-134	51940.0
135-139	57809.0
140-144	64587.0
145-149	2339100.0
150-152	2.712897E7
>>END_MODULE
>>Sequence Duplication Levels	fail
#Total Deduplicated Percentage	20.62731849204396
#Duplication Level	Percentage of deduplicated	Percentage of total
1	78.17240871671363	16.124871718898852
2	11.513758104225696	4.749959109124314
3	3.8856798546195086	2.4045346775806697
4	1.851129764665623	1.5273537290344077
5	1.0243153387112092	1.0564439363940998
6	0.6539962408093652	0.8094113251064551
7	0.4644390439676473	0.6706092456042748
8	0.340203005612984	0.5613980598983711
9	0.2588328078506205	0.48051240873522877
>10	1.457228595948354	5.631114487843031
>50	0.146107376410585	2.1312921137076373
>100	0.14788491525572264	6.512491911000268
>500	0.030164565350737436	4.377841103269306
>1k	0.04070715978052969	18.783557427499645
>5k	0.007984677550212201	11.536220249656589
>10k+	0.005159832527335492	22.64238849664678
>>END_MODULE
>>Overrepresented sequences	warn
#Sequence	Count	Percentage	Possible Source
CCCGACTGTCCCTGTTAATCATTACTCCGGTCCCGAAGGCCAACACAATA	149974	0.500709294208026	No Hit
CTGCCAGTAGTCATATGCTTGTCTCAAAGATTAAGCCATGCATGTGTAAG	119039	0.39742844541873396	No Hit
CCGGAACCCAAAAACTTTGATTTCTCATAAGGTGCCGGCGGTGTCCTAAG	114519	0.3823377896395971	No Hit
CCTGCCAGTAGTCATATGCTTGTCTCAAAGATTAAGCCATGCATGTGTAA	114131	0.3810423970638659	No Hit
CCCAACTTTCGTTCTTGATTAATGAAAACATCCTTGGCAAATGCTTTCGC	107447	0.3587269228984342	No Hit
CGCGTGTTTAGCTTGGATTCTGACTTAGAGGCGTTCAGTCATAATCCGAC	70061	0.23390850321728107	No Hit
CTTACCAGGTCCAGACATAGTAAGGATTGACAGACTGAGAGCTCTTTCTT	65190	0.2176459845667997	No Hit
CGCGCCTGCTGCCTTCCTTGGATGTGGTAGCCGTTTCTCAGGCTCCCTCT	63785	0.21295519444076266	No Hit
CCGACATCGAAGGATCAAAAAGCAACGTCGCTATGAACGCTTGGCTGCCA	60545	0.20213799870527513	No Hit
CGCGGCTGCTGGCACCAGACTTGCCCTCCAATGGATCCTCGTTAAGGGAT	59474	0.1985623145593779	No Hit
CTGCTGCCTTCCTTGGATGTGGTAGCCGTTTCTCAGGCTCCCTCTCCGGA	58940	0.19677948044741791	No Hit
TGCCAGTAGTCATATGCTTGTCTCAAAGATTAAGCCATGCATGTGTAAGT	58321	0.19471286187943435	No Hit
CACGCTTTCACGGTTCGTATTCGTACTGGAAATCAGAATCAAACGAGCTT	56953	0.19014560145778406	No Hit
GCCAGTAGTCATATGCTTGTCTCAAAGATTAAGCCATGCATGTGTAAGTA	51803	0.17295160206341348	No Hit
CTCCTACTCATCGGGGCATGGCAATCGCCCCGACGGCCGGGTATGGGTCG	51769	0.17283808828100405	No Hit
CTCGATTCCGTGGCGCGGCTCAACGGAGCAGCCGCGCCGTCCTACCTATT	51609	0.17230390577554786	No Hit
CCAACTTTCGTTCTTGATTAATGAAAACATCCTTGGCAAATGCTTTCGCA	51465	0.17182314152063732	No Hit
GTCTGACATGTGTGCGAGTCGACGGGCGAGTAAACCCGTAAGGCGCAAGG	51312	0.17131232949979483	No Hit
CTTGCTTTGAGCACTCTAATTTCTTCAAAGTAACAGCGCCGGTGGTGCGG	51045	0.17042091244381485	No Hit
CTTCCGTCAATTCCTTTAAGTTTCAGCCTTGCGACCATACTCCCCCCGGA	47088	0.15720991135575185	No Hit
GCGCCTGCTGCCTTCCTTGGATGTGGTAGCCGTTTCTCAGGCTCCCTCTC	46191	0.1542151506845382	No Hit
CCCGGCTTCCGGTTCATCCCGCATCGCCAGTTCTGCTTACCAAAAATGGC	43878	0.1464928748400374	No Hit
CCCCAACTTTCGTTCTTGATTAATGAAAACATCCTTGGCAAATGCTTTCG	42742	0.14270017905129853	No Hit
CCCTCTTCGGCCTTCAAAGTTCTCATTTGAATATTTGCTACTACCACCAA	42437	0.14168189365027273	No Hit
CTGACATGTGTGCGAGTCGACGGGCGAGTAAACCCGTAAGGCGCAAGGAA	42362	0.14143149560084015	No Hit
GTTAATCATTACTCCGGTCCCGAAGGCCAACACAATAGGACCGAAATCCT	41444	0.13836662347578532	No Hit
CTGTGATGTTATCCCATGCTAATGTATCCAGAGCGTAGGCTTGCTTTGAG	40344	0.13469411875077414	No Hit
CCCCGACTGTCCCTGTTAATCATTACTCCGGTCCCGAAGGCCAACACAAT	39252	0.13104832315103576	No Hit
CTCCAATGGATCCTCGTTAAGGGATTTAGATTGTACTCATTCCAATTACC	39121	0.1306109612246935	No Hit
CGCCTGCTGCCTTCCTTGGATGTGGTAGCCGTTTCTCAGGCTCCCTCTCC	38319	0.12793337141609445	No Hit
CCGAAGGCCAACACAATAGGACCGAAATCCTGTGATGTTATCCCATGCTA	37471	0.12510220413717674	No Hit
CTCCGTCACCCGTCACCACCACAGTAGGCCCCTATCCTACCGTCGAAAGT	36800	0.12286197625491989	No Hit
CCCCACCTGACAATGTCTTCCGCCCGGATCGGCCCGCCGAGGCGGGCCTT	36465	0.12174353163412104	No Hit
CCTCGCGGTACTTGTTCGCTATCGGTCTCTCGCCGGTATTTAGCCTTGGA	36288	0.12115259223746015	No Hit
GCGGTTATGAGTACGACCGGGCGTGGGAGGCACTCGGTCCTCCGGATTTT	35799	0.1195199969551597	No Hit
GGCGTGGGCACCCGCTGAATTTAAGCATATCAATAAGCGGAGGAGAAGAA	35463	0.11839821369370176	No Hit
CCGGCTTCCGGTTCATCCCGCATCGCCAGTTCTGCTTACCAAAAATGGCC	33998	0.11350710512811867	No Hit
CCGACTGTCCCTGTTAATCATTACTCCGGTCCCGAAGGCCAACACAATAG	33482	0.11178436654802251	No Hit
ACCAGGTCCAGACATAGTAAGGATTGACAGACTGAGAGCTCTTTCTTGAT	33285	0.1111266543381796	No Hit
CTTTTGTTCCACACGAGATTTCTGTTCTCGTTGAGCTCATCTTAGGACAC	32934	0.10995479146683511	No Hit
CTGCAAAGGATTCTGCCCGCCGTCCGGTCGAAATTAATCTTCAAGGCGGC	32645	0.1089899243163549	No Hit
CAAAAGGGTAAAAGCTCGTTTGATTCTGATTTCCAGTACGAATACGAACC	32058	0.10703014224946257	No Hit
CCGGAATCGAACCCTAATTCTCCGTCACCCGTCACCACCACAGTAGGCCC	31704	0.10584826345614079	No Hit
CGGGCGGCGGGCGCGAGCGCCGCGTGTTTAGCTTGGATTCTGACTTAGAG	31690	0.10580152248691335	No Hit
GTCGGCATCGTTTATGGTTGAGACTAGGACGGTATCTAATCGTCTTCGAG	31563	0.10537751512320753	No Hit
GCGGCGGGCGCGAGCGCCGCGTGTTTAGCTTGGATTCTGACTTAGAGGCG	31403	0.10484333261775135	No Hit
CCCGCATCGCCAGTTCTGCTTACCAAAAATGGCCCACTTGGAGCTCTCGA	31242	0.10430581147163606	No Hit
CCACGCTTTCACGGTTCGTATTCGTACTGGAAATCAGAATCAAACGAGCT	30806	0.10285016414426801	No Hit
CCCGGAACCCAAAAACTTTGATTTCTCATAAGGTGCCGGCGGTGTCCTAA	30768	0.10272329579922217	No Hit
CGAGGATCCATTGGAGGGCAAGTCTGGTGCCAGCAGCCGCGGTAATTCCA	30536	0.10194873116631072	No Hit
CCAAGATCCGCACCGACGGCCGCTCCGCCCGGGCTCGCGCCCCGGGTTTT	30011	0.10019594482028264	No Hit
>>END_MODULE
>>Adapter Content	pass
#Position	Illumina Universal Adapter	Illumina Small RNA 3' Adapter	Illumina Small RNA 5' Adapter	Nextera Transposase Sequence	SOLID Small RNA Adapter
1	0.0	0.0	3.3386406591010844E-6	0.0	1.669320329550542E-5
2	0.0	0.0	6.677281318202169E-6	0.0	5.675689120471843E-5
3	0.0	0.0	6.677281318202169E-6	0.0	1.9697979888696397E-4
4	0.0	0.0	1.0015921977303253E-5	3.3386406591010844E-6	2.0365708020516615E-4
5	3.3386406591010844E-6	0.0	1.3354562636404338E-5	6.677281318202169E-6	2.1033436152336833E-4
6	6.677281318202169E-6	0.0	1.3354562636404338E-5	6.677281318202169E-6	2.1033436152336833E-4
7	6.677281318202169E-6	0.0	1.669320329550542E-5	6.677281318202169E-6	2.1033436152336833E-4
8	6.677281318202169E-6	0.0	1.669320329550542E-5	6.677281318202169E-6	2.136730021824694E-4
9	6.677281318202169E-6	0.0	1.669320329550542E-5	6.677281318202169E-6	2.4705940877348023E-4
10-14	2.7376853404628893E-5	0.0	2.0699572086426723E-5	6.677281318202168E-6	2.904617373417944E-4
15-19	7.47855507638643E-5	0.0	4.0731416041033235E-5	6.677281318202168E-6	3.425445316237713E-4
20-24	2.5841078701442394E-4	0.0	5.007960988651627E-5	7.3450094500223856E-6	3.525604536010745E-4
25-29	9.949149164121232E-4	0.0	5.675689120471844E-5	1.0015921977303253E-5	3.81940491401164E-4
30-34	0.0022121833007203782	0.0	6.343417252292061E-5	1.0015921977303253E-5	4.440392076604442E-4
35-39	0.0033633465999784325	6.009553186381952E-6	7.411782263204408E-5	1.936411582278629E-5	5.415275149061959E-4
40-44	0.004946530000524167	9.348193845483035E-6	9.615285098211123E-5	2.6041397140988457E-5	6.423544628110487E-4
45-49	0.006796136925666167	1.0015921977303253E-5	1.1084286988215602E-4	2.9380037800089542E-5	7.511941482977439E-4
50-54	0.0083132152411617	1.0015921977303253E-5	1.1685242306853794E-4	3.338640659101084E-5	8.086187676342827E-4
55-59	0.009596588710520156	1.0015921977303253E-5	1.228619762549199E-4	3.605731911829171E-5	8.847397746617874E-4
60-64	0.010844572588892142	1.4022290768224553E-5	1.4756791713226792E-4	3.672504725011193E-5	9.308130157573823E-4
65-69	0.012090553282868666	2.0699572086426723E-5	1.6025475163685204E-4	3.672504725011193E-5	9.8489899443482E-4
70-74	0.013200317437953867	2.4038212745527808E-5	1.7027067361415532E-4	3.672504725011193E-5	0.0010850582142078523
75-79	0.01433612299018006	3.1383222195550195E-5	1.8362523625055965E-4	3.672504725011193E-5	0.0011938978996945478
80-84	0.015503311764601796	3.405413472283106E-5	1.8496069251420008E-4	4.273460043649389E-5	0.0012847089256220973
85-89	0.01675129564297378	3.8728231645572576E-5	1.903025175687618E-4	4.674096922741518E-5	0.0013635008451768828
90-94	0.01812147376946887	4.006368790921301E-5	1.903025175687618E-4	4.674096922741518E-5	0.001434947755281646
95-99	0.019703321713750957	4.2066872304673664E-5	1.9631207075514377E-4	4.674096922741518E-5	0.001545790625163802
100-104	0.02139400934351975	4.74086973592354E-5	2.0499253646880656E-4	4.674096922741518E-5	0.001649956213727756
105-109	0.02321490395899348	5.1415066150156704E-5	2.150084584461098E-4	4.9411881754696044E-5	0.0017614668117417322
110-114	0.0252468006641224	5.341825054561734E-5	2.2368892415977268E-4	5.341825054561734E-5	0.0018562842064602028
115-119	0.027556472272088527	5.341825054561734E-5	2.296984773461546E-4	5.341825054561734E-5	0.0019657916200787186
120-124	0.030017718165977852	5.341825054561734E-5	2.3370484613707588E-4	5.341825054561734E-5	0.0021066822558927843
125-129	0.03238882076207144	5.5421434941077996E-5	2.3370484613707588E-4	5.341825054561734E-5	0.0022028351068748954
130-134	0.034132926642385854	5.675689120471844E-5	2.3570803053253654E-4	6.009553186381952E-5	0.0022829624826933214
135-139	0.03561394763876309	6.076325999563974E-5	2.383789430598174E-4	6.009553186381952E-5	0.0023403871020298605
140	0.035756841458972614	6.343417252292061E-5	2.4038212745527808E-4	6.009553186381952E-5	0.0023938053525754776
>>END_MODULE
