Effects of Avocado (Persea americana) on Metabolic Syndrome: A Comprehensive Systematic Review

 

Effects of Avocado (Persea americana) on Metabolic Syndrome: A Comprehensive Systematic Review

. 2017 Jun;31(6):819-837.

doi: 10.1002/ptr.5805. Epub 2017 Apr 10.

Authors

Jamshid Tabeshpour1 2, Bibi Marjan Razavi3 , Hossein Hosseinzadeh4

Affiliations

  • 1 Department of Pharmacodynamics and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.
  • 2 Student Research Committee, Mashhad University of Medical Sciences, Mashhad, Iran.
  • 3 Targeted Drug Delivery Research Center, Department of Pharmacodynamy and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.
  • 4 Pharmaceutical Research Center, Department of Pharmacodynamics and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.

Abstract

Metabolic syndrome (MetS) is a clustering of risk factors including high blood glucose, dyslipidemia, hypertension, and obesity that lead to the increased risk of type 2 diabetes mellitus and cardiovascular diseases (CVDs), which are among leading causes of death in the world. Metabolic syndrome increases the risk of type 2 diabetes mellitus and CVDs by approximately five and three folds, respectively. Therefore, it is of vital importance to manage such conditions with herbal options which have less undesirable adverse effects and may be more efficacious in comparison with synthetic options. Avocado is a well-known source of carotenoids, minerals, phenolics, vitamins, and fatty acids. The lipid-lowering, antihypertensive, antidiabetic, anti-obesity, antithrombotic, antiatherosclerotic, and cardioprotective effects of avocado have been demonstrated in several studies. In this review, we aimed to find out avocado's pharmacological effects on different components of MetS. Moreover, this review report is performed on the MetS effects of peel, seed, flesh, and leaves of avocado. Copyright © 2017 John Wiley & Sons, Ltd.

Keywords: Persea americana; avocado; cardiovascular diseases; diabetes; metabolic syndrome; obesity.

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